Electrophysiological alterations in rat atrial muscle with metabolic syndrome
Alteraciones electrofisiológicas en el músculo auricular de rata con síndrome metabólico
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Main Article Content
The current lifestyle has increased the prevalence of Metabolic Syndrome (MS) which has been related to the most common arrhythmia worldwide: atrial fibrillation. In a rat model with MS, changes in the sinoatrial node have been reported, however, the role of the atrial muscle in this pathology remains unknown. The objective of this work is to determine whether MS generates supraventricular arrhythmias in a rat model and its relationship with alterations in the morphology of the atrial action potential. Methods: male Wistar rats were used to which SM was induced. Metabolic and morphometric parameters were measured, in vivo electrocardiogram (ECG) and atrial action potentials (PA) were recorded in an isolated tissue preparation where excitability was measured. Results: in the animals of the SM group, alterations were observed in the ECG such as biphasic P wave and notched P wave related to the decrease in the duration of the PA during repolarization in the endocardium of the right atrium and left atrial epicardium, transmural changes were also observed on the duration of the AP in both atria and a shift to the right on the excitability graph of the SM group records. Concussions: MS remodels the supraventricular electrical activity and, by modifying the transmural heterogeneity of the atria, increases excitability. It is proposed that these changes contribute to the generation and maintenance of supraventricular arrhythmias.
