Role of mitochondria in the Sepsis Rol de la mitocondria en la Sepsis Review of the literature and translational approach.

Abstract

The mitochondria is a complex organization, its main function is the production of energy in the form of ATP, essential for life. Semi-autonomous since it has mtDNA capable of producing some main respiratory chain proteins. Alterations in enzyme physiology due to inhibition of these structures may explain the alterations in oxygen consumption "cytopathic hypoxia" in sepsis. In addition, its components have been detected as producers of a dysregulated inflammatory response by having powerful DAMPs in its structure such as mtDNA and cytochrome C, which perpetuate or trigger oxidative stress, which are clinically associated as producers of multiorgan dysfunction and mortality in the patient with septic shock. Therefore, its components can also be used as biomarkers for diagnosis and prognosis, in addition to becoming pharmacological targets. Knowledge of the role of the mitochondria in sepsis is of vital importance in clinical practice. In this review article we will try to explain the pathophysiology of mitochondrial dysfunction in sepsis, and transfer them to clinical applicability